Germline mutations in BRCA1 and BRCA2 account for majority of hereditary breast and ovarian cancer. The complete coding sequence analysis of both genes was carried out in 197 breast/ovarian cancer patients from high-risk families and 53 patients with sporadic breast/ovarian cancer. In summary, 59 mu
InheritedBRCA2mutations in African Americans with breast and/or ovarian cancer: a study of familial and early onset cases
β Scribed by Yasmine Kanaan; Elikem Kpenu; Kim Utley; Lucile Adams-Campbell; Georgia M. Dunston; Lawrence C. Brody; Carolyn Broome
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 268 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0340-6717
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The entire coding regions of BRCA1 and BRCA2 were screened for mutations by heteroduplex analysis in 51 Mexican breast cancer patients. One BRCA1 and one BRCA2 truncating mutation each was identified in the group of 32 (6%) early-onset breast cancer patients (< or =35 years). Besides these two likel
## Abstract Germβline mutations within __BRCA1__ are responsible for different proportions of inherited susceptibility to breast/ovarian cancer, and the spectrum of mutations within this gene is often unique to certain populations. At this time, there have been no reports regarding the role of __BR
Here we report the study on BRCA1 and BRCA2 mutations in 12 Thai breast and/or ovarian cancer families and 6 early-onset breast or breast/ovarian cancer cases without a family history of cancer. Five distinct rare alterations were identified in each gene: four introducing premature stop codons, one