BRCA1 germline mutations and tumor characteristics in Chinese women with familial or early-onset breast cancer
โ Scribed by Weiqiu Chen; Kaifeng Pan; Tao Ouyang; Jinfeng Li; Tianfeng Wang; Zhaoqing Fan; Tie Fan; Benyao Lin; Youyong Lu; Weicheng You; Yuntao Xie
- Publisher
- Springer US
- Year
- 2008
- Tongue
- English
- Weight
- 172 KB
- Volume
- 117
- Category
- Article
- ISSN
- 0167-6806
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๐ SIMILAR VOLUMES
Germline mutations in BRCA1 and BRCA2 account for majority of hereditary breast and ovarian cancer. The complete coding sequence analysis of both genes was carried out in 197 breast/ovarian cancer patients from high-risk families and 53 patients with sporadic breast/ovarian cancer. In summary, 59 mu
Mutations in the familial early-onset breast cancer gene (BRCA1) account for approximately 2-5% of all breast cancer cases (Easton et al., 1993). Since the isolation of the BRCA1 gene in 1994, many mutations have been identified. We report here a total of 254 BRCA1 mutations, 132 (52%) of which are
Germline mutations in the BRCA1 and BRCA2 genes are responsible for the predisposition and development of familial breast and/or ovarian cancer. Most mutations of BRCA1 and BRCA2 associated with breast and/or ovarian cancer result in truncated proteins. To investigate the presence of BRCA1 and BRCA2