Influence of XPD variant alleles on p53 mutations in lung tumors of nonsmokers and smokers
✍ Scribed by Sai-Mei Hou; Annamaria Kannio; Sabrina Angelini; Susann Fält; Fredrik Nyberg; Kirsti Husgafvel-Pursiainen
- Book ID
- 117549979
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 48 KB
- Volume
- 1236
- Category
- Article
- ISSN
- 0531-5131
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## Abstract The etiology of lung cancer in population with little or no tobacco exposure is not well understood. Individual genetic susceptibility factors have been suggested to contribute to lung cancer risk in this population. Mutations in the p53 tumor suppressor gene are implicated in the devel
## Abstract Our previous study showed a characteristic p53 mutational spectrum in lung tumors from lung cancer patients in the Western Pennsylvania region. To further understand the involvement of p53 mutations in lung tumor development, in this study we compared p53 mutational spectra and distribu
## Background: An accumulation of mutations can result in carcinogenesis. comparing genetic alterations in preneoplastic lesions with those seen in cancer in the same patient may be helpful in the early diagnosis of lung carcinoma or preneoplastic lesions. ## Methods: To identify genetic alterati