Influence of wettability and surface activity on release behavior of hydrophilic substances from lipid matrices
✍ Scribed by S. Koennings; A. Berié; J. Tessmar; T. Blunk; A. Goepferich
- Book ID
- 113691513
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 873 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0168-3659
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📜 SIMILAR VOLUMES
Weakly basic drugs and their salts exhibit a drop in aqueous solubility at high pH conditions, which can result in low and incomplete release of these drugs from sustained release formulations. The objective of this study is to modulate matrix microenvironmental pH by incorporation of acidic polymer
The influence of tablet hardness and density variation o n in vitro dissolution of dye from controlled release tablets made with different types and viscosity grades of hydrophilic polymers was investigated. Tablet volumes were maintained constant and the weight varied to obtain varying degrees of h