Utilisation of hydrophilic gums for the control of drug substance release from tablet formulations II. Influence of tablet hardness and density on dissolution behavior

✍ Scribed by H. E. Huber; G. L. Christenson

• Publisher: John Wiley and Sons
• Year: 1968
• Tongue: English
• Weight: 288 KB
• Volume: 57
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600570135

✦ Synopsis

The influence of tablet hardness and density variation o n in vitro dissolution of dye from controlled release tablets made with different types and viscosity grades of hydrophilic polymers was investigated. Tablet volumes were maintained constant and the weight varied to obtain varying degrees of hardness and density. Tablets made at varying hardness did not show markedly different release characteristics as evaluated by an in vitro method. Different release patterns were, however, observed with tablets prepared from different gums.