Influence of micro-environmental pH on the gel layer behavior and release of a basic drug from various hydrophilic matrices

Influence of methacrylic and acrylic aci

Influence of methacrylic and acrylic acid polymers on the release performance of weakly basic drugs from sustained release hydrophilic matrices

✍ Aditya S. Tatavarti; Ketan A. Mehta; Larry L. Augsburger; Stephen W. Hoag 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 231 KB 👁 2 views

Weakly basic drugs and their salts exhibit a drop in aqueous solubility at high pH conditions, which can result in low and incomplete release of these drugs from sustained release formulations. The objective of this study is to modulate matrix microenvironmental pH by incorporation of acidic polymer