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Influence of the Length and Positioning of the Antiestrogenic Side Chain of Endoxifen and 4-Hydroxytamoxifen on Gene Activation and Growth of Estrogen Receptor Positive Cancer Cells

✍ Scribed by Maximov, Philipp Y.; Fernandes, Daphne J.; McDaniel, Russell E.; Myers, Cynthia B.; Curpan, Ramona F.; Jordan, V. Craig

Book ID: 125530743
Publisher: American Chemical Society
Year: 2014
Tongue: English
Weight: 791 KB
Volume: 57
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm500569h

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## Abstract Although tamoxifen (TAM) is used for the front‐line treatment and prevention of estrogen receptor‐positive (ER+) breast tumors, nearly 40% of estrogen‐dependent breast tumors do not respond to TAM treatment. Moreover, the positive response is usually of short duration, and most tumors e