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Influence of substrate structure on cleavage by hammerhead ribozyme

✍ Scribed by Daniela Scarabino; Glauco P. Tocchini-Valentini


Book ID
115932208
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
540 KB
Volume
383
Category
Article
ISSN
0014-5793

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Replacement of the Cleavable Phosphodies
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A nucleoside dimer in which the natural phosphodiester bond is replaced by an isosteric amide linkage has been prepared. This dimer analogue was subsequently incorporated chemically at the cleavage position of a hammerhead ribozyme substrate. Although the resulting substrate analogue