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Design of allosteric hammerhead ribozymes activated by ligand-induced structure stabilization

✍ Scribed by Garrett A Soukup; Ronald R Breaker

Book ID
114329736
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
106 KB
Volume
7
Category
Article
ISSN
0969-2126

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## Abstract Ribozyme possesses specific endoribonuclease activity and catalyzes the hydrolysis of specific phosphodiester bonds, which results in the cleavage of target RNA sequences. Here, we evaluated the ability of hammerhead ribozymes targeting human telomerase RNA (hTR) to inhibit the catalyti