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Influence of quinine and quinidine on the pharmacokinetics of phdenprocoumon in rat and man

✍ Scribed by H. Iven; L. Lerche; M. Kaschube

Book ID
115884290
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
105 KB
Volume
183
Category
Article
ISSN
0014-2999

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## Abstract Metoprolol is a β‐blocker and its racemic mixture is used for the treatment of hypertension. In the present study we investigated the influence of CYP2D and CYP3A on the stereoselective metabolism of metoprolol in rats. Male Wistar rats (__n__ = 6 per group) received racemic metoprolol