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Influence of quinidine, fluvoxamine, and ketoconazole on the enantioselective pharmacokinetics of citalopram in rats

✍ Scribed by Rocha, Adriana; Coelho, Eduardo B.; Lanchote, Vera L.

Book ID
121265551
Publisher
NRC Research Press
Year
2008
Tongue
French
Weight
134 KB
Volume
86
Category
Article
ISSN
0008-4212

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## Abstract Metoprolol is a β‐blocker and its racemic mixture is used for the treatment of hypertension. In the present study we investigated the influence of CYP2D and CYP3A on the stereoselective metabolism of metoprolol in rats. Male Wistar rats (__n__ = 6 per group) received racemic metoprolol