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Influence of probenecid (PR) and cimetidine (C) on pramipexole (PX) pharmacokinetics.

✍ Scribed by Wright, C.E.; Lasher Sissson, T.; Ichhpurani, A.K.; Peters, G.R.


Book ID
110019661
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
143 KB
Volume
59
Category
Article
ISSN
0009-9236

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## Abstract Metoprolol is a β‐blocker and its racemic mixture is used for the treatment of hypertension. In the present study we investigated the influence of CYP2D and CYP3A on the stereoselective metabolism of metoprolol in rats. Male Wistar rats (__n__ = 6 per group) received racemic metoprolol