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Influence of cimetidine on verapamil kinetics and dynamics

✍ Scribed by Smith, Mark S; Benyunes, Mark C; Bjornsson, Thorir D; Shand, David G; Pritchett, Edward L C

Book ID
109843470
Publisher
Nature Publishing Group
Year
1984
Tongue
English
Weight
246 KB
Volume
36
Category
Article
ISSN
0009-9236

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Following cimetidine administration, 60% of the dose is excreted as unchanged drug in the urine, and 40% is eliminated by metabolism. We evaluated the effect of liver disease on cimetidine disposition by comparing its kinetics in 7 healthy subjects and 8 patients with alcoholic cirrhosis. Cirrhotic