Influence of cimetidine on the pharmacokinetics of desmethyldiazepam and oxazepam
β Scribed by U. Klotz; I. Reimann
- Publisher
- Springer
- Year
- 1980
- Tongue
- English
- Weight
- 452 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0031-6970
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## Abstract Metoprolol is a Ξ²βblocker and its racemic mixture is used for the treatment of hypertension. In the present study we investigated the influence of CYP2D and CYP3A on the stereoselective metabolism of metoprolol in rats. Male Wistar rats (__n__ = 6 per group) received racemic metoprolol
A possible interaction between the calcium antagonist nimodipine and the H2-receptor antagonists cimetidine and ranitidine has been investigated in two separate studies in healthy subjects. In eight young volunteers the concomitant administration of nimodipine 30 mg t.i.d. and cimetidine 1000 mg/d f