Influence of piperacillin on the pharmacokinetics of methotrexate and 7-hydroxymethotrexate
β Scribed by Tawfeeg A. Najjar; Hisham S. Abou-Auda; Naushad M. Ghilzai
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 188 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0344-5704
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π SIMILAR VOLUMES
Stable label analogues of methotrexate (MTX) and 7-hydroxymethotrexate (7-OH-MTX) were required for use as internal standards for LC/MS quantitation. A minimum incorporation of stable isotopes to produce a mass increase of 3 in the non-glutamate derived portion of the molecule was necessary for adeq
In rabbits the IV kinetics of MTX (1.33, 4 and 12 mg/kg) could be described by a linear three-compartment model with a terminal half-life between 2.4 and 3.6 h. During 8 h 50% of the dose was excreted into urine in unchanged form and 15% as the metabolite 7-OH-MTX. These fractions remained constant