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Influence of O6-benzylguanine on the anti-tumour activity and normal tissue toxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and molecular combinations of 5-fluorouracil and 2-chloroethyl-1-nitrosourea in mice

✍ Scribed by Bibby, M C; McElhinney, R S

Book ID: 110001077
Publisher: Nature Publishing Group
Year: 1999
Tongue: English
Weight: 385 KB
Volume: 79
Category: Article
ISSN: 0007-0920
DOI: 10.1038/sj.bjc.6690215

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## Abstract The effects of single‐agent therapy with two clinically useful drugs, 5‐fluorouracil (5‐FU) and 1‐3‐bis‐(2‐chloro‐ethyl)‐1‐nitrosourea (BCNU) against nine human colorectal tumors (rectum T 157 and T 348, lung metastasis T 84, lymph‐node metastasis T 245, colon, T 183, T 219, T 347, T 36