Influence of netropsin's charges on the minor groove width of d(CGCGAATTCGCG)2
✍ Scribed by Bernd Wellenzohn; Wolfgang Flader; Rudolf H. Winger; Andreas Hallbrucker; Erwin Mayer; Klaus R. Liedl
- Book ID
- 101717597
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2002
- Tongue
- English
- Weight
- 181 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0006-3525
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## Abstract The structure of a neutral glyco‐conjugate β‐Gal‐Py‐**γ**‐Py‐Ind (**1**), designed as a probe for analyzing sugar–DNA interactions, when bound to a self‐complementary oligonucleotide duplex d(CGCG AATT CGCG)~2~ has been deduced by employing ^1^H NMR techniques. Analysis of the formed 1:
The structures of the complexes formed between two anticancer minor-groove-binding quinolinium quaternary salts and the dodecamer d(CGCGAATTCGCG) 2 have been refined to resolutions of 1.6 and 1.8 A ˚. The complexes crystallized in space group P2 1 2 1 2 1 and the structures are isomorphous with prev