𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Influence of metyrapone and phenobarbital on sodium dichromate nephrotoxicity in developing rats

✍ Scribed by D. Appenroth; S. Gambaryan; K.-H. Friese; H. Bräunlich

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
617 KB
Volume
10
Category
Article
ISSN
0260-437X

No coin nor oath required. For personal study only.

✦ Synopsis

After the administration of equal doses of sodium dichromate, chromium concentrations in the kidney were lower in young than in adult rats. To test the age-dependent sensitivity to the nephrotoxicity of dichromate, young and adult rats were given doses to achieve identical chromium concentrations in the kidney. At equal renal concentrations, young rats had less functional and morphological damage than adult rats. As phenobarbital treatment in young rats enhanced the symptoms of nephrotoxicity and metyrapone treatment in adult rats decreased the symptoms of nephrotoxicity, age-dependent differences in chromate nephrotoxicity may be linked to an increase in the enzymatic reduction of Cr(V1) with age.

📜 SIMILAR VOLUMES

The influence of phenobarbital on carboh
The influence of phenobarbital on carbohydrate metabolism in developing rat liver
✍ Jürgen Schaub; Almuth Friedrich-Freksa 📂 Article 📅 1976 🏛 Springer 🌐 English ⚖ 440 KB

The influences of phenobarbital (PB) on enzymes of the carbohydrate metabolism in rat liver are examined during pre-and postnatal development. The following results are obtained: (1) PB generally increases G-6-Pase before and after birth. (2) Both the active and the inactive forms of phosphorylase a

Phenobarbital influences the development
Phenobarbital influences the development of sodium retention in liver disease induced by bile duct ligation in the rat
✍ Georg Wensing; Robert A. Branch 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 676 KB

The onset of sodium retention in phenobarbitalharbon tetrachloride-induced cirrhosis in rats is preceded by a linear decrease in hepatic function as assessed by the aminopyrine rate constant of elimination. Sodium retention occurs when liver function decreases below a critical aminopyrine rate const

Effect of β-naphthoflavone and phenobarb
Effect of β-naphthoflavone and phenobarbital on the nephrotoxicity of chlorotrifluoroethylene and 1,1-dichloro-2,2-difluoroethylene in the rat
✍ Georges Morel; Masarin Ban; Pierre Bonnet; Danièle Zissu; Marie-Thérèse Brondeau 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 901 KB

## Abstract The role of cytochrome P450 activity in the nephrotoxicity of chlorotrifluoroethylene (CTFE) and 1,1‐dichloro‐2,2‐difluoroethylene (DCDFE) was investigated in the male rat. Hepatic cytochrome P450 1A1 and principally P450 2B1[sol ]2 were induced by __β__‐naphthoflavone and phenobarbital

Influence of chronic lead exposure on ho
Influence of chronic lead exposure on hormone levels in developing rats
✍ Adolf Vyskočil; Zdeněk Fiala; Eva Ettlerová; Iva Tenjnorová 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 138 KB 👁 1 views

## Abstract The effect of five months' exposure to 0.5% lead acetate in drinking water on hormone levels of developing rats was studied. The hypothalamic and striatic concentrations of noradrenaline (NA) were decreased in both sexes. In female but not in male rats, blood and adrenal catecholamines