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The influence of phenobarbital on carbohydrate metabolism in developing rat liver

✍ Scribed by Jürgen Schaub; Almuth Friedrich-Freksa

Publisher
Springer
Year
1976
Tongue
English
Weight
440 KB
Volume
122
Category
Article
ISSN
0340-6997

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✦ Synopsis

The influences of phenobarbital (PB) on enzymes of the carbohydrate metabolism in rat liver are examined during pre-and postnatal development. The following results are obtained: (1) PB generally increases G-6-Pase before and after birth. (2) Both the active and the inactive forms of phosphorylase are increased significantly during the prenatal periods. During the postnatal periods, mainly the active form of phosphorylase is influenced by PB.

(3) Total glycogen synthetase is increased by PB during prenatal development but decreased during postnatal development. (4) The activity of a-glucosidase is increased during the prenatal period. ( 5) The activity of F-6-PK and 6-PGDtt arc decreased during the prenatal periods and G-6-PDI:I activity is decreased during both pre-and postnatal periods.

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