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Influence of interferon on virus particle formation in different oncornavirus carrier cell lines

✍ Scribed by A. Billiau; H. Sobis; P. De Somer

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
620 KB
Volume
12
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Three types of oncornavirus‐carrying mouse cell lines were studied. Replication of endogenous sarcoma or leukemia viruses in cell lines producing the infectious viruses was as sensitive to inter feron as that of exogenous vesicular stomatitis virus (VSV). Replication of non‐infectious C‐type virus in S^+^L^−^ cells which carry a rescuable Moloney sarcoma virus (MSV) genome did not respond to interferon. However, this cell line was also found to be 70 times less responsive to interferon when tested by an exogenous VSV challenge. Finally, after exposure to interferon, M04 cells, which carry a rescuable MSV genome and produce non‐infectious A‐type particles, developed normal resistance to VSV. Yet, high doses of interferon could not prevent the induction of surplus A‐type particles by bromodeoxyuridine (BDU) and dimethylsulfoxide (DMSO). The results are interpreted as indicating that non‐infectious A‐type particles are synthetized by a mechanism different from that by which infectious C‐type particles are generated.

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Influence of interferon on virus-particl
Influence of interferon on virus-particle synthesis in oncornavirus-carrier lines. II. Evidence for A direct effect on particle release
✍ A. Billiau; V. G. Edy; H. Sobis; P. De Somer 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 French ⚖ 382 KB 👁 1 views

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Influence of interferon on the synthesis of virus particles in oncornavirus carrier cell lines. III. Survey of effects on A-, B- and C-type oncornaviruses
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## Abstract The effect of interferon on the synthesis and release of A‐, B‐ and C‐type viruses by oncornavirus carrier lines was studied. Murine cell lines were selected which carry either of these viruses and are sensitive to the antiviral effect of interferon, as measured by inhibition of vesicul