✦ LIBER ✦

Influence of interferon on virus-particle synthesis in oncornavirus-carrier lines. II. Evidence for A direct effect on particle release

✍ Scribed by A. Billiau; V. G. Edy; H. Sobis; P. De Somer

Publisher: John Wiley and Sons
Year: 1974
Tongue: French
Weight: 382 KB
Volume: 14
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910140306

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✦ Synopsis

Abstract

Interferon treatment of murine C‐type oncornavirus carrier lines results in a drastic inhibition of extracellular virus formation. When such cells are subcultured in the presence of interferon, synthesis of extracellular C‐type virus remains depressed until the interferon treatement is discontinued. Cell‐associated virus as seen in the electron microscope or as detected by uridine incorporation is not proportionally inhibited. Several possibilities to explain this discrepancy are tested. The most likely hypothesis is that interferon treatment primarily inhibits virus release.

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Influence of interferon on the synthesis of virus particles in oncornavirus carrier cell lines. III. Survey of effects on A-, B- and C-type oncornaviruses

✍ A. Billiau; V. G. Edy; E. DeClercq; H. Heremans; P. DeSomer 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 French ⚖ 475 KB 👁 1 views

## Abstract The effect of interferon on the synthesis and release of A‐, B‐ and C‐type viruses by oncornavirus carrier lines was studied. Murine cell lines were selected which carry either of these viruses and are sensitive to the antiviral effect of interferon, as measured by inhibition of vesicul