𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Influence of interferon on the synthesis of virus particles in oncornavirus carrier cell lines. III. Survey of effects on A-, B- and C-type oncornaviruses

✍ Scribed by A. Billiau; V. G. Edy; E. DeClercq; H. Heremans; P. DeSomer

Publisher
John Wiley and Sons
Year
1975
Tongue
French
Weight
475 KB
Volume
15
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The effect of interferon on the synthesis and release of A‐, B‐ and C‐type viruses by oncornavirus carrier lines was studied. Murine cell lines were selected which carry either of these viruses and are sensitive to the antiviral effect of interferon, as measured by inhibition of vesicular stomatitis virus. Release of C‐type virus was found to be highly sensitive. Release of B‐type virus, on the contrary, was only marginally inhibited. Synthesis of intracisternal A‐type particles was finally not inhibited by interferon pretreatment. These differences between infectious C‐type and non‐infectious A‐ and B‐type viruses may reflect fundamental differences in the synthesis of these viruses.

📜 SIMILAR VOLUMES

Influence of interferon on virus-particl
Influence of interferon on virus-particle synthesis in oncornavirus-carrier lines. II. Evidence for A direct effect on particle release
✍ A. Billiau; V. G. Edy; H. Sobis; P. De Somer 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 French ⚖ 382 KB 👁 1 views

## Abstract Interferon treatment of murine C‐type oncornavirus carrier lines results in a drastic inhibition of extracellular virus formation. When such cells are subcultured in the presence of interferon, synthesis of extracellular C‐type virus remains depressed until the interferon treatement is

Characterization of the effects of hepat
Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon-sensitive virus replication
✍ Stephen J. Polyak; Denise M. Paschal; Susan McArdle; Michael J. Jr.; Darius Mora 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 338 KB 👁 1 views

The hepatitis C virus (HCV) nonstructural 5A (NS5A) protein has been implicated in the inherent resistance of HCV to interferon (IFN) antiviral therapy in clinical studies. Biochemical studies have demonstrated that NS5A interacts in vitro with and inhibits the IFN-induced, RNAdependent protein kina