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Influence of gluten-derived fractions on chemiluminescence production by human neutrophils

✍ Scribed by Roccatello, D. ;Amprimo, M. Claudia ;Coppo, Rosanna ;Cavalli, G. ;Quattrocchio, G. ;Gianoglio, B. ;Ferrerc, A. ;Mauro, Clelia Di ;Sena, L. M. ;Piccoli, G.

Publisher: John Wiley and Sons
Year: 1990
Weight: 350 KB
Volume: 5
Category: Article
ISSN: 0884-3996
DOI: 10.1002/bio.1170050303

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✦ Synopsis

The effects of gliadin and glyc-gli on leukocyte chemiluminescence response were assessed in vitro. A dose-dependent increase in chemiluminescence response of neutrophils stimulated by zymosan was observed by using gliadin at concentrations ranging between 1 and 20 pg. By increasing glyc-gli concentration, a bimodal response was observed with an enhancement up t o 50 pg/ml, followed by suppressive effects, which were again dose-dependent. The possible implications of these findings in human pathology are discussed.

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