## Abstract **BACKGROUND:** The influence of methanol feed rate on recombinant human growth hormone (rhGH) production by __Pichia pastoris__ hGH‐Mut^+^ in medium containing sorbitol was investigated at three different specific growth rates (µ), namely, 0.02 (MS‐0.02), 0.03 (MS‐0.03), and 0.04 (MS‐0
Influence of pH on recombinant human growth hormone production by Pichia pastoris
✍ Scribed by Pınar Çalık; Eda Bayraktar; Bahar İnankur; Elif Ş. Soyaslan; Merve Şahin; Hatice Taşpınar; Eda Açık; Remziye Yılmaz; Tunçer H. Özdamar
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2010
- Tongue
- English
- Weight
- 267 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0268-2575
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract A recombinant avidin‐producing Mut^+^ __Pichia pastoris__ strain was used as a model organism to study the influence of the methanol feeding strategy on the specific product productivity (q~p~) and protein glycosylation. Fed‐batch cultivations performed at various specific growth rates
The aerobic fed-batch production of recombinant human growth hormone (rhGH) by Escherichia coli was studied. The goal was to determine the production and protein degradation pattern of this product during fed-batch cultivation and to what extent scale differences depend on the presence of a fed-batc
An unstructured growth model for the recombinant methylotrophic yeast P. pastoris Mut + expressing the heavy-chain fragment C of botulinum neurotoxin serotype A [BoNT/A(H c )], was successfully established in quasi-steady state fed-batch fermentations with varying cell densities. The model describes
## Abstract Growth hormone (GH), given therapeutically in many human diseases, is able to modulate the maturation and function of many cells of immune system. The present study demonstrates the effect of human recombinant GH on the production of acute phase proteins (APP) as well as on the gene exp