The analysis of the new antimetabolite 2 ', 2 '-difluoro2 '-deoxycytidine (Gemcitabine, Eli Lilly Corp.) and of its metabolic deamination product, \(2^{\prime}, 2^{\prime}\)-difluoro-2'deoxyuridine, in urine and plasma by means of \({ }^{19} \mathrm{~F}\) NMR is described. Both compounds show AB-typ
✦ LIBER ✦
Influence of gemcitabine (2′,2′-difluoro-deoxycytidine) and 2-chlorodeoxyadenosine on growth of normal and leukemic cellsin vitro
✍ Scribed by Ewa Lech-Marańda; Anna Korycka; Tadeusz Robak
- Book ID
- 114422846
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 79 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0902-4441
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## Abstract __cis__‐Dichlorodiammineplatinum and 5‐aza‐2′‐deoxycytidine display a considerable synergistic effect in L1210 and La mouse leukemia __in vivo__; the combination of both drugs is also clearly synergistic __in vitro__as evidenced by the effects on cell growth and cell survival in soft‐ag