✦ LIBER ✦

Synergistic effect of cis-dichlorodiammineplatinum and 5-aza-2′-deoxycytidine on mouse leukemic cells in vivo and in vitro

✍ Scribed by J. Veselý

Publisher: John Wiley and Sons
Year: 1982
Tongue: French
Weight: 444 KB
Volume: 29
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910290114

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✦ Synopsis

Abstract

cis‐Dichlorodiammineplatinum and 5‐aza‐2′‐deoxycytidine display a considerable synergistic effect in L1210 and La mouse leukemia in vivo; the combination of both drugs is also clearly synergistic __in vitro__as evidenced by the effects on cell growth and cell survival in soft‐agar medium. In exponential but not in stationary growth of L1210 cells, the drugs interfere with DNA and RNA synthesis.

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