Influence of food on the pharmacokinetics of dipyrone
โ Scribed by D. Flusser; E. Zylber-Katz; L. Granit; M. Levy
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 281 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0031-6970
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract The effect of food intake on the pharmacokinetics of DEPAKINEยฎ CHRONO 500 mg (Sanofi, France), a sustained release formulation containing 333 mg sodium valproate and 145 mg valproic acid, was studied in 12 young healthy female volunteers. Relative to fasting conditions (F), when the tab
Administration of terfenadine (Seldane@) immediately after a high fat breakfast slightly affects the rate but not the extent of absorption relative to fasting administration. Mean peak levels of the active metabolite were increased by 13 per cent but delayed by 0.9 h while AUC was virtually the same
Bioavailability of avitriptan was found to decrease significantly when administered 5 min after a standard high fat meal. The studies described herein were carried out to gain insight into the mechanism of this food effect. A series of studies were conducted in humans to assess the effect of timing