The effect of short-term dipyrone administration on cyclosporin pharmacokinetics
โ Scribed by Y. Caraco; E. Zylber-Katz; M. Fridlander; D. Admon; M. Levy
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 84 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0031-6970
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๐ SIMILAR VOLUMES
The effect of IntralipidTM co-administration on the pharmacokinetics of cyclosporine (CyA) was studied in NZW rabbits. A single intravenous bolus dose of CyA (10mg kg-') mixed with 3 ml of Intralipid was administered to rabbits (n = 4). Control animals (n = 4) received the same dose of CyA without I
The disposition of chlordiazepoxide (Librium@) and diazepam (Valium@), compounds which are initially degraded by oxidative processes, differs from that of oxazepam (Serafi) and lorazepam (AtivanB), drugs which are inactivated by conjugation with glucuronic acid. Liver disease and cimetidine impair t
Abbreviations: AUC, area under the curve; AUC 0-1 , area under the curve from time 0 to infinity; CI, confidence interval(s); CL/F, apparent clearance; C max , maximum concentration; CRU, Clinical Research Unit; CYP3A, cytochrome P450 3A; DN, dose-normalized; F, oral bioavailability; GLS mean ratio(