Influence of antacids on the bioavailability of trimoprostil
β Scribed by R. J. Wills; M. M. C. Rees; F. Rubio; D. M. Gibson; S. Givens; M. Parsonnet; H. E. Gallo-Torres
- Publisher
- Springer
- Year
- 1984
- Tongue
- English
- Weight
- 316 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0031-6970
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Two 200mg quinidine sulfate tablets were administered to nine healthy male subjects in the fasting state, immediately after a balanced meal, and with 30ml of aluminum hydroxide gel using a complete crossover design. Serum and urine samples were taken over 32 and 60 h, respectively. Quinidine concent
## Abstract Concomitant administration of antacid increased the maximum concentration (__Cp__~max~) and the area under the plasma concentrationβtime curve (AUC) of 100 mg oral dose of metoprolol by 25 per cent (__p__< 0.05) and 11 per cent (__p__ < 0.1) respectively. For atenolol the opposite effec