✦ LIBER ✦

Effect of food and an antacid on quinidine bioavailability

✍ Scribed by Louis N. Ace; James M. Jaffe; Robert L. Kunka

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 415 KB
Volume: 4
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510040210

No coin nor oath required. For personal study only.

✦ Synopsis

Two 200mg quinidine sulfate tablets were administered to nine healthy male subjects in the fasting state, immediately after a balanced meal, and with 30ml of aluminum hydroxide gel using a complete crossover design. Serum and urine samples were taken over 32 and 60 h, respectively. Quinidine concentrations were measured using a highperformance liquid chromatography assay specific for quinidine. Computer fitting of the data to several models indicated that a one-compartment model with zero-order absorption and a lag time best fit all the data. Quinidine elimination.and urine pH were unaffected by the study conditions. While the maximum serum concentration (CmaX) and area under the serum concentration-time curve (AUC) were unaffected by administration of quinidine with food or antacid, there was a 44 per cent increase (p<O.lO) in time to C,,, (fmaX) following quinidine administration with food. Thus, while the extent of quinidine absorption was unaffected by food or the antacid used, the rate of quinidine absorption was significantly reduced by food as reported earlier.

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