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Industrially Viable Preparation of (R)-3-Quinuclidinol, a Key Building Block of Muscarine M1, M3 Agonists and M3 Antagonists

✍ Scribed by Chavakula, Ramadas; Mutyala, Narayana Rao; Chennupati, Srinivasa Rao


Book ID
121328353
Publisher
Taylor and Francis Group
Year
2013
Tongue
English
Weight
150 KB
Volume
45
Category
Article
ISSN
0030-4948

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Pharmacological in vitro characterizatio
✍ Eddi Meier; Kristen Frederiksen; Mogens Nielsen; Hanne LΓΈve LembΓΈl; Henrik Peder πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 210 KB πŸ‘ 1 views

The arecoline bioisostere, Lu 25-109-T, displays a pharmacological profile of a partial muscarinic agonist with a several-fold higher affinity for cortical M 1 receptors than for brain stem M 2 receptors and salivary glands M 3 receptors. The compound is selective for muscarinic receptors as it show