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Induction of wasting disease in SCID mice by the transfer of normal CD4+/CD45RBhi T cells and the regulation of this autoreactivity by CD4+/CD45RBlo T cells

✍ Scribed by Morrissey, P.J.; Charrier, K.


Book ID
122697908
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
447 KB
Volume
145
Category
Article
ISSN
0923-2494

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CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta