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Biochemical Association of CD45 with the T Cell Receptor Complex: Regulation by CD45 Isoform and during T Cell Activation

โœ Scribed by David Leitenberg; Yvan Boutin; Dan Dan Lu; Kim Bottomly


Book ID
117722498
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
331 KB
Volume
10
Category
Article
ISSN
1074-7613

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CD4, CD8 and the role of CD45 in T-cell
โœ Jeffrey A. Ledbetter; Julie P. Deans; Alejandro Aruffo; Laura S. Grosmaire; Stev ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 1009 KB

CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta