๐”– Bobbio Scriptorium
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Induction of tolerance by monoclonal antibody therapy

โœ Scribed by Benjamin, R. J.; Waldmann, H.


Book ID
109743239
Publisher
Nature Publishing Group
Year
1986
Tongue
English
Weight
395 KB
Volume
320
Category
Article
ISSN
0028-0836

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The therapeutic effectiveness of xenogeneic monoclonal antibodies (MAbs) (xIg) or their conjugates with toxins (xIg-Tx) is undermined because of their inherent immunogenicity. This complication may be overcome by converting the antigenic xIg to tolerogenic derivatives by coupling an appropriate numb