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Induction of tolerance in peripheral T cells with monoclonal antibodies

✍ Scribed by Shixin Qin; Matt Wise; Stephen P. Cobbold; Louise Leong; Yi-Chi M. Kong; Jane R. Parnes; Herman Waldmann

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
866 KB
Volume
20
Category
Article
ISSN
0014-2980

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✍ Pradip K. Maiti; Glen M. Lang; A. H. Sehon πŸ“‚ Article πŸ“… 1988 πŸ› John Wiley and Sons 🌐 French βš– 576 KB

The therapeutic effectiveness of xenogeneic monoclonal antibodies (MAbs) (xIg) or their conjugates with toxins (xIg-Tx) is undermined because of their inherent immunogenicity. This complication may be overcome by converting the antigenic xIg to tolerogenic derivatives by coupling an appropriate numb