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The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance

✍ Scribed by Todd N. Eagar; Nitin J. Karandikar; Jeffrey A. Bluestone; Stephen D. Miller

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
157 KB
Volume
32
Category
Article
ISSN
0014-2980

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To asses the requirement of interleukin (IL)-10 for peripheral CD4 T cell tolerance, the IL-10 knockout (KO) was introduced into a T cell receptor-transgenic mouse model (TCR1) specific for SV40 T antigen (Tag). IL-10-deficient TCR1-transgenic mice failed to establish antigen-specific T cell toleran