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Induction of the metabolism of etizolam by carbamazepine in humans

✍ Scribed by S. Kondo; T. Fukasawa; N. Yasui-Furukori; T. Aoshima; A. Suzuki; Y. Inoue; T. Tateishi; K. Otani


Publisher
Springer
Year
2005
Tongue
English
Weight
194 KB
Volume
61
Category
Article
ISSN
0031-6970

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48-h steady-state metabolic balance studies were carried out in 17 adults receiving long-term anticonvulsant monotherapy. With increasing carbamazepine dosage (1) carbamazepine overall plasma apparent clearance (CL/F), (2) plasma clearance of carbamazepine to urinary carbamazepine-10,11-epoxide, (3)

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Six healthy young adult male volunteers were given two 600 mg (2540 g moles) oral doses of carbamazepine (CBZ) 5 days apart. Serial concentrations of CBZ and its 10,11-epoxy (CBZ-epoxide) and 10,11-dihydro-lO,11-trans-dihydroxy (CBZ-diol) metabolites in plasma, and daily excretions of these substanc