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Inhibition of the metabolism of etizolam by itraconazole in humans: evidence for the involvement of CYP3A4 in etizolam metabolism

โœ Scribed by K. Araki; N. Yasui-Furukori; T. Fukasawa; T. Aoshima; A. Suzuki; Y. Inoue; T. Tateishi; K. Otani

Publisher
Springer
Year
2004
Tongue
English
Weight
183 KB
Volume
60
Category
Article
ISSN
0031-6970

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In Vitro/in Vivo scaling of alprazolam m
In Vitro/in Vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans
โœ Noriko Hirota; Kiyomi Ito; Takafumi Iwatsubo; Carol E. Green; Charles A. Tyson; ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 243 KB ๐Ÿ‘ 1 views

We attempted to predict the in vivo metabolic clearance of alprazolam from in vitro metabolic studies using human liver microsomes and human CYP recombinants. Good correlations were observed between the intrinsic clearance (CL int ) for 4-hydroxylation and CYP3A4 content and between the CL int for a