Induction of tetraploidy through loss of p53 and upregulation of Plk1 by human papillomavirus type-16 E6
β Scribed by Incassati, A; Patel, D; McCance, D J
- Book ID
- 110070300
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 305 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0950-9232
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We and others have previously reported that human papillomavirus (HPV)-16 E6 protein expression sensitizes certain cell types to apoptosis. To confirm that this sensitization occurred in HPV's natural host cells, and to explore the mechanism(s) of sensitization, we infected human keratinocytes (HKCs
Certain types of human papillomavirus (HPV), such as types 16 and 18, are etiological agents for carcinogenesis of the uterine cervix. These HPVs have two oncogenes, E6 and E7, that have transforming activities in established murine cells. Tumorigenicity and decreased serum requirement for cell grow