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Induction of sister-chromatid exchanges by N-nitrosocimetidine in cultured human lymphocytes and its inhibition by chemical compounds

✍ Scribed by Kiyoshi Inoue; Tadayoshi Shibata; Hiroaki Kosaka; Mitsuro Uozumi; Shoichiro Tsuda; Tatsuo Abe

Book ID
119092760
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
359 KB
Volume
156
Category
Article
ISSN
0165-1218

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Induction of sister chromatid exchanges
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✍ Ünal Egeli πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 51 KB πŸ‘ 2 views

This study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/m