Induction of microsomal epoxide hydrolas
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R. Sellman; M. G. Parkki
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Article
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1983
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John Wiley and Sons
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English
β 405 KB
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The effects of tienilic acid [ 2,3-dichloro-4-(2-thienylcarbonyl)phenoxy acetic acid] on drug-metabolizing enzymes in the rat liver and kidneys were studied. Short-term treatment for 2 weeks (450 mg per kg per day) increased the activity of microsomal epoxide hydrolase at least two-fold in both rat