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Induction of cytosolic and microsomal epoxide hydrolases by the hypolipidaemic compound nafenopin in the mouse liver

✍ Scribed by Felix Waechter; Françoise Bieri; Willy Stäubli; Philip Bentley

Book ID
115777621
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
406 KB
Volume
33
Category
Article
ISSN
0006-2952

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Induction of microsomal epoxide hydrolas
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✍ R. Sellman; M. G. Parkki 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 English ⚖ 405 KB 👁 1 views

The effects of tienilic acid [ 2,3-dichloro-4-(2-thienylcarbonyl)phenoxy acetic acid] on drug-metabolizing enzymes in the rat liver and kidneys were studied. Short-term treatment for 2 weeks (450 mg per kg per day) increased the activity of microsomal epoxide hydrolase at least two-fold in both rat