Enhancement of epoxide hydrolase activity in hepatic microsomes of mice given heterocyclic compounds
β Scribed by Henry S. Heine; Michael K. Stoskopf; David C. Thompson; Young-Nam Cha
- Book ID
- 114009365
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 851 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0009-2797
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Microsomal epoxide hydrolase (mEH) is inducible by a number of xenobiotics. Induction of mEH by certain chemopreventive agents may implicate the protective effect. In contrast, many of carcinogenic agents also induce the enzyme. The hepatotoxicity and mEH expression by methylthiazoles, which are inc
## Abstract Microsomal epoxide hydrolase (mEH) and cytochrome Pβ450 (CYP) ensure the rapid detoxification of epoxides generated during the oxidative metabolism of xenobiotics. Although CYP has been demonstrated to modulate methamphetamine (METH)βinduced behavioral effects, little is known about the