Induction of macrophage differentiation of the human promyelocytic cell line HL-60: A study of peroxidatic activity
β Scribed by Robert H.J. Beelen; Inge L. Eestermans; Wim Jalink; Harry J. Bos; Hert J. Ossenkoppele
- Book ID
- 103684351
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 200 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0304-3991
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## Abstract Various compounds active in promoting in vitro differentiation of certain murine leukemia cell lines (Friend erythroleukemia cells and mouse myeloid leukemia cells) were tested for their capacity to induce differentiation of HLβ60 cells, a human promyelocytic leukemia cell line capable
Human promyelocytic leukaemic cells, HLβ60, arrested in mitosis by nocodazole were released in the presence of 1Ξ±,25βdihydroxyvitamin D3 and thymidine or hydroxyurea. Cells moved from early G1 period to the G1/S boundary and differentiated. Furthermore, cells arrested at the G1/S boundary by double