✦ LIBER ✦

TERMINAL DIFFERENTIATION OF HUMAN PROMYELOCYTIC LEUKAEMIA CELLS, HL-60, DURING THE G1 PERIOD

✍ Scribed by Tadao Matsuhisa

Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 84 KB
Volume: 25
Category: Article
ISSN: 1065-6995
DOI: 10.1006/cbir.2000.0588

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✦ Synopsis

Human promyelocytic leukaemic cells, HL‐60, arrested in mitosis by nocodazole were released in the presence of 1α,25‐dihydroxyvitamin D3 and thymidine or hydroxyurea. Cells moved from early G1 period to the G1/S boundary and differentiated. Furthermore, cells arrested at the G1/S boundary by double thymidine block were released, with 1α,25‐dihydroxyvitamin D3 being added at the end of DNA synthesis. Under the latter conditions, differentiated cells developed, indicating that DNA synthesis is not required for cell differentiation.

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