Induction of interferon in AKR mice by murine leukaemia viruses
β Scribed by Blank, Kenneth J.; Murasko, Donna Marie
- Book ID
- 109717475
- Publisher
- Nature Publishing Group
- Year
- 1980
- Tongue
- English
- Weight
- 248 KB
- Volume
- 283
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/283494a0
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## Abstract Daily administration of potent mouse interferon preparations, begun after clinical diagnosis of lymphoma in AKR mice, increased average survival by approximately 100%. Interferon treatment delayed the evolution of the lymphoma but regression of tumor was not observed. The therapeutic ef
## Abstract The intrasplenic inoculation of AKR lymphoma cells into 1βmonthβold BALB mice, followed by a syngeneic intraperitoneal passage, led to the development of shortβlatency leukemia of host origin within 24 days; the incidence of leukemia averaged 83% in 88 mice. Electron microscopic studies
## Abstract The time course of development of thymic lymphoma, which occurs spontaneously in mice of the AKR strain, is accelerated by the methylating agents __N__βmethylβ__N__βnitrosourea (MNU) and methyl methanesulphonate (MMS). Since MNU is a potent mutagen inducing G β A transition mutations an