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Induction of leukemia in balb mice by allogeneic AKR leukemic cells

✍ Scribed by Christiane Dosne Pasqualini; Fortuna Saal; R. C. Braylan; S. L. Rabasa

Publisher
John Wiley and Sons
Year
1970
Tongue
French
Weight
620 KB
Volume
5
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The intrasplenic inoculation of AKR lymphoma cells into 1‐month‐old BALB mice, followed by a syngeneic intraperitoneal passage, led to the development of short‐latency leukemia of host origin within 24 days; the incidence of leukemia averaged 83% in 88 mice. Electron microscopic studies revealed the presence of intracisternal A and extracellular C‐type viral particles in leukemic lymph nodes. These results were obtained with eight AKR lymphoma inocula out of 107 trials and were never observed in BALB controls and with normal AKR spleen inoculum, except in one animal. In the surviving groups, the incidence of long‐latency leukemia, averaging 19 months, was significantly increased to 45% in the 541 mice which had received AKR lymphoma inocula, as compared to 30% in those receiving normal AKR spleen inocula; the latter value was also significantly higher than the 15% spontaneous incidence of the BALB strain. A number of tumors were observed in the experimental groups. Antigenic studies, using the indirect cytotoxic test, demonstrated the presence of the G (Gross) antigen, in both short‐ and long‐latency leukemias.

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