## Abstract Thymuses of 14‐day‐old AKR mouse embryos were infected with Gross murine leukemia virus (MuLV) and then maintained in organ culture for 3 weeks. When they were transplanted to 3‐week‐old (AKR X C3H)F~1~ mice, approximately 50% of these developed T lymphomas within 3–4 months. Most (22/2
Interferon and murine leukemia. VII. Therapeutic effect of interferon preparations after diagnosis of lymphoma in akr mice
✍ Scribed by Ion Gresser; Chantal Maury; Michael Tovey
- Publisher
- John Wiley and Sons
- Year
- 1976
- Tongue
- French
- Weight
- 388 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Daily administration of potent mouse interferon preparations, begun after clinical diagnosis of lymphoma in AKR mice, increased average survival by approximately 100%. Interferon treatment delayed the evolution of the lymphoma but regression of tumor was not observed. The therapeutic effects observed with interferon in AKR mice compare favorably with reported results obtained using standard anti‐cancer drugs.
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## Abstract Rauscher murine leukemia virus (R‐MuLV) induces a rapidly developing erythroleukemia in BALB/c mice. Previously, we have shown that mouse interferon‐α/β (Mu IFN‐α/β) applied shortly after virus inoculation efficiently inhibits the leukemic process (Hekman __et al.__, 1981). Here we desc