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Anti-tumor effects of interferon in mice injected with interferonsensitive and interferon-resistant friend leukemia cells. VI. Adjuvant therapy after surgery in the inhibition of liver and spleen metastases

✍ Scribed by Ion Gresser; Chantal Maury; Filippo Belardelli

Publisher
John Wiley and Sons
Year
1987
Tongue
French
Weight
661 KB
Volume
39
Category
Article
ISSN
0020-7136

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Mouse interferon a@? exerted a similar anti-tumor effect in DBA/2 mice injected i.p. with Friend erythroleukemia cells (FLC) either sensitive or resistant to interferon as determined by both in vitro and in vivo assays. Using this tumor system we attempted to define optimal treatment regimens for in

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## Abstract Administration of highly purified interferon to DA/2 mice inhibited the growth of interferon‐sensitive or interferon‐resistant Friend erythroleukemia cells implanted subcutaneously. Injection of interferon at the site of tumor inoculation was more effective than injection of interferon

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Interferon treatment markedly inhibits the development of tumor metastases in the liver and spleen and increases survival time of mice after intravenous inoculation of friend erythroleukemia cells
✍ Ion Gresser; Chantal Maury; David Woodrow; Jill Moss; Marcus G. Grütter; Françoi 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 French ⚖ 980 KB

respectively. Solid arrows indicate easily visible foci of tumor cells against background of normal hepatic parenchyma. In (c) the hepatic parenchyma is totally replaced by tumor except for small island of normal liver indicated by an open arrow. Hematoxylin and eosin. X 20.