Anti-tumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant friend erythroleukemia cells. VIII. Role of the immune system in the inhibition of visceral metastases

✍ Scribed by Ion Gresser; Chantal Maury; Claude Carnaud; Edward De Maever; Marie-Thérése Maunoury; Filippo Belardelli

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: French
• Weight: 758 KB
• Volume: 46
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910460324

✦ Synopsis

DBAl2 mice were injected i.v. with IFN alp-resistant 3C I 8 Friend erythroleukemia cells (FLC) which metastasize to the liver and spleen. IFN d p treatment of FLC-injected mice increased their survival time and these mice developed a resistance to a second challenge with FLC. The efficacy of IFN d p in increasing the survival time was compared between normal immunocompetent and immunodeficient mice. The antitumor action of IFN was markedly reduced or abolished in newborn DBAl2 mice, in adult athymic nu/nu and beige DBAl 2 mice, and in BALB/c scidscid mice. To determine the phenotype of the effector cells involved, FLC-injected DBN2 mice were treated with antibodies to asialo-GMI, CD4, or CD8 antigens, or with cyclosporin A or silica. IFN a/p treatment proved much less effective in these mice, indicating that a variety of effector cell types participated in the IFN-induced suppression of visceral metastases. Thus, an intact immune system appears to be essential to obtain optimal therapeutic effects of IFN df! in this experimental model.